A Child With Recurrent Jaw Swelling
A 9-year-old male presented with a 2-year history of recurrent left-sided jaw swelling. Physical examination revealed a hard mass at the left ramus of the mandible. What is your diagnosis?
Medical Knowledge
A Destructive Midfacial Mass in a Middle-Aged Man
A 43-year-old man presented with a destructive mass on the nose, with multiple areas of erosion, ulcers, and exudate covering the mass. Histological examination showed polymorphous lymphocytic infiltration in the full-thickness dermis. What is your diagnosis?
Isolated Diffuse Precentral Gyrus Signals in Creutzfeldt-Jakob Disease
This case report describes a woman with Creutzfeldt-Jakob disease with findings largely confined to the right precentral gyrus on initial imaging.
Therapies to Decrease Severe Respiratory Syncytial Virus Illness
This JAMA Insights discusses the use of monoclonal antibodies or protein-based vaccines to help prevent severe RSV infection in infants, children, and older adults.
Papule Protruding Into the Nasal Cavity
An 18-year-old male with no significant medical history presented for evaluation of a nasal papule that was asymptomatic without any associated pain, pruritus, or bleeding with no changes for a year. What is your diagnosis?
Accounting for Competing Risks in Clinical Research
This JAMA Guide to Statistics and Methods article discusses accounting for competing risks in clinical research.
Clinical Practice Guideline for Red Blood Cell Transfusion Thresholds in Very Preterm Neonates
Importance Red blood cell (RBC) transfusion is a common medical intervention to treat anemia in very preterm neonates; however, best transfusion practices, such as thresholds, remain uncertain. Objective To develop recommendations for clinicians on the use of RBC transfusions in very preterm…
International Consensus on Standard Outcome Measures for Neurodevelopmental Disorders – A Consensus Statement
Importance The use of evidence-based standardized outcome measures is increasingly recognized as key to guiding clinical decision-making in mental health. Implementation of these measures into clinical practice has been hampered by lack of clarity on what to measure and how to…
Low-Dose Corticosteroids for Critically Ill Adults With Severe Pulmonary Infections – A Review
Importance Severe pulmonary infections, including COVID-19, community-acquired pneumonia, influenza, and Pneumocystis pneumonia, are a leading cause of death among adults worldwide. Pulmonary infections in critically ill patients may cause septic shock, acute respiratory distress syndrome, or both, which are associated with mortality rates…
Management of Depression in Adults – A Review
Importance Approximately 9% of US adults experience major depression each year, with a lifetime prevalence of approximately 17% for men and 30% for women. Observations Major depression is defined by depressed mood, loss of interest in activities, and associated psychological and somatic…
