Medical Knowledge

Unusual Tachycardia in a Patient With Chest Pain and Bradycardia

This case report describes a patient in their 50s who presented with squeezing chest pain for 4 hours and an initial electrocardiogram showing acute inferior wall and right ventricular infarction with third-degree atrioventricular block.

Maculopathy in a 52-Year-Old Patient With Diabetes

A 52-year-old woman with severe nonproliferative diabetic retinopathy had decreased vision and macular edema in both eyes that was not responding to treatment. What would you do next?

Fever, Rash, and Shortness of Breath in a 69-Year-Old

A 69-year-old had fever, fatigue, rash, right periorbital swelling, and shortness of breath. Chest computed tomography revealed numerous small, bilateral pulmonary nodules; laboratory testing revealed mean corpuscular volume, 96.1 fL; hemoglobin level, 12.4 mg/dL; and leukopenia. What is the diagnosis…

Posterior Segment Changes in Gaucher Disease

This case report discusses posterior segment characteristics in a patient aged 24 years with low vision and a history of Gaucher disease.

RNA Interference With Zilebesiran for Mild to Moderate Hypertension – The KARDIA-1 Randomized Clinical Trial

Importance  Angiotensinogen is the most upstream precursor of the renin–angiotensin–aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an investigational RNA interference therapeutic, targets hepatic angiotensinogen synthesis. Objective  To evaluate antihypertensive efficacy and safety of different zilebesiran dosing regimens. Design,…

Diagnosis and Management of Paroxysmal Supraventricular Tachycardia

Importance  Paroxysmal supraventricular tachycardia (PSVT), defined as tachyarrhythmias that originate from or conduct through the atria or atrioventricular node with abrupt onset, affects 168 to 332 per 100 000 individuals. Untreated PSVT is associated with adverse outcomes including high symptom burden and…