Importance The ways in which we access, acquire, and use data in clinical trials have evolved very little over time, resulting in a fragmented and inefficient system that limits the amount and quality of evidence that can be generated. Observations Clinical trial…
Importance Obesity affects approximately 21% of US adolescents and is associated with insulin resistance, hypertension, dyslipidemia, sleep disorders, depression, and musculoskeletal problems. Obesity during adolescence has also been associated with an increased risk of mortality from cardiovascular disease and type 2…
This Teachable Moment describes a 62-year-old man with thyrotoxicosis due to excess levothyroxine exposure during tirzepatide treatment that induced rapid weight loss.
A man in his 70s presented with 2 enlarging, painless nodular lesions on the forehead and right cheek. Histopathological examination showed extensive dermal collection of lymphocytes, histiocytes, and macrophages. What is your diagnosis?
This JAMA Insights reviews the health effects of vaping among youth in the US and current recommendations for screening and treatment.
This case report discusses progressive cardiogenic shock in a man aged 78 years after catheter ablation for ventricular tachycardia.
This JAMA Insights explores the adverse effects and health outcomes of e-cigarettes vs combusted cigarettes and the effectiveness of using e-cigarettes as a smoking cessation aid among US adults.
This article discusses the ACGME requirement that sponsoring institutions of postgraduate medical training provide trainees with at least 6 weeks of paid parental leave throughout their training period.
Importance Acute myeloid leukemia (AML) is a clonal hematopoietic cancer that disrupts normal hematopoiesis, ultimately leading to bone marrow failure and death. The annual incidence rate of AML is 4.1 per 100 000 people in the US and is higher in…
This case report describes a 67-year-old woman who had received adoptive immunotherapy with chimeric antigen receptor T cells for multiple myeloma and was experiencing parkinsonism-like symptoms.
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