Activity ID
14492Expires
September 19, 2026Format Type
InternetCME Credit
12.50Fee
$100 - Physicians In-Person; $75 Non-Physicians In Person; $200 Physicians Live Stream; $150 Non-Physicians Live StreamCME Provider: Cleveland Clinic
Description of CME Course
Primary immunodeficiency (PI) disorders, also called inborn errors of immunity, are a group of nearly 500 disorders characterized by abnormalities in the immune system. These disorders have a relatively rare prevalence, with approximately 1% to 2% of the global population estimated to be afflicted with PI, with about 500,000 cases in the United States.
These disorders are caused by genetic mutations that affect the development or function of the immune system and are present from birth, although they may not become apparent until later in life. There are various types of PI disorders, each affecting different immune system components, such as T cells, B cells, phagocytes, and complement proteins, resulting in increased susceptibility to infection, potentially resulting in serious, life-threatening infections, organ damage, secondary malignancies, and autoimmune diseases.
Symptoms of PI disorders can vary widely but generally include recurrent, unusual, or severe infections. Symptoms can involve multiple organ systems, including respiratory, gastrointestinal, and skin issues. Diagnosis often involves a combination of clinical evaluation, family history report, blood tests to assess immune function (eg, immunoglobulin levels, lymphocyte counts), and genetic testing to identify specific mutations, but it is often challenging given the complex nature of the disorder.
This CME-certified activity will provide a robust, two-day educational schedule that addresses various clinical topics relevant to immunodeficiency, which have gaps in knowledge, competence, and practice among healthcare professionals that are defined in the attached Needs Assessment. Through presentations by experts that review and analyze the most current relevant research and interpret the findings for their implications for clinical practice, it will address those gaps, with the ultimate goal of improving patient outcomes.
ABMS Member Board Approvals by Type
ABMS Lifelong Learning CME Activity
Allergy and Immunology
Commercial Support?
NoNOTE: If a Member Board has not deemed this activity for MOC approval as an accredited CME activity, this activity may count toward an ABMS Member Board’s general CME requirement. Please refer directly to your Member Board’s MOC Part II Lifelong Learning and Self-Assessment Program Requirements.
Educational Objectives
• Provide an update on common variable immunodeficiency syndrome and research on IgE levels in immunodeficiency.
• Describe advances in specific antibody deficiency and utilize vaccine testing guidelines.
• Summarize recent advancements in identifying and treating hematologic complications including chronic neutropenia and immune thrombocytopenia.
• Discuss the increased cancer risks in immunocompromised patients and their implications for cancer screening.
• Review the clinical presentation, pathogenesis, diagnosis, and treatment of various immune disorders caused by cellular defects.
• Recognize, assess, and diagnose common symptoms seen in immunocompromised patients.
• Define uses of artificial intelligence to improve and individualize therapy in patients with immune dysfunction.
• Critically appraise innovations in immunoglobulin replacement therapy, gene therapy, and stem cell transplantation in the treatment of immunodeficiency syndromes.
• Summarize the efficacy, side effects, and clinical implications of therapeutic options in management strategies for patients with complex immunodeficiency diseases.
Keywords
Immunodeficiency, Allergy, Immunology, IgE
Competencies
Medical Knowledge, Patient Care & Procedural Skills
CME Credit Type
AMA PRA Category 1 Credit
Practice Setting
Inpatient, Outpatient
