Justice in CRISPR/Cas9 Research and Clinical Applications

Activity ID

4444

Expires

August 31, 2021

Format Type

Journal-based CME

CME Credit

Fee

$20

CME Provider

American Medical Association

Description

CRISPR/Cas9 is a rapidly developing gene editing technology that will soon have many clinical applications. As with many other new technologies, somatic gene editing with CRISPR/Cas9 raises concerns about equitable access to therapies by historically disenfranchised racial and ethnic minorities. We describe justice concerns related to CRISPR/Cas9, including its potential impact on historically mistreated populations through underrepresentation of minorities in genomic databases and the potential for disparate access to somatic gene therapies when they become clinically available. We then describe ongoing work that aims to address these justice concerns. We conclude by highlighting important considerations to ensure equitable access to therapies going forward, including enhancing diversity in genomic sequencing efforts, improving education and transparency, and building partnerships with underserved and socially disenfranchised communities.

doi:10.1001/amajethics.2018.826

Disclaimers
1. This activity is part of the AMA Journal of Ethics.
2. This activity is free to AMA members.

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General Information
Additional

Educational Objectives

1. Explain a new or unfamiliar viewpoint on a topic of ethical or professional conduct.
2. Evaluate the usefulness of this information for his or her practice, teaching, or conduct.
3. Decide whether and when to apply the new information to his or her practice, teaching, or conduct.

Keywords

Ethics, Genetics and Genomics

Competencies

Medical Knowledge, Professionalism

CME Credit Type

AMA PRA Category 1 Credit

Additional Information

doi:10.1001/amajethics.2018.826