Activity ID



May 22, 2023

Format Type


CME Credit



CME Provider

Louisiana Medical Mutual Insurance Company (LAMMICO)


While professional society guidelines differ in their grading of the recommendation to administer intravenous tissue plasminogen activator (IV tPA) for treatment of ischemic stroke, there is evidence that giving tPA within established parameters can improve some patients’ outcomes. Patients with acute ischemic strokes have the right to be informed of the risks, benefits and alternatives of treatment with tPA andwith their physicians to make an informed choice about its use. In addition, many patients with large vessel occlusions are candidates for endovascular treatment. Patients considered for endovascular therapy for clot extraction should receive IV tPA within the 4.5-hour window prior to transfer to an intervention-capable facility.

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NOTE: If a Member Board has not deemed this activity for MOC approval as an accredited CME activity, this activity may count toward an ABMS Member Board’s general CME requirement. Please refer directly to your Member Board’s MOC Part II Lifelong Learning and Self-Assessment Program Requirements.

Educational Objectives

Develop and dialogue to present risk and benefits data for tPA therapy to patients
Describe differences between ACEP and AHA/ASA guidelines for the use of tPA in acute ischemic stroke
Document in patients' records the medical rationale and the patient's stated goals concerning treatment with tPA
List and discuss steps for initial treatment and potential transfer of stroke patients who could benefit from endovascular intervention


emergency department, ED, stroke


Medical Knowledge, Patient Care & Procedural Skills

CME Credit Type

AMA PRA Category 1 Credit

Practice Setting

Inpatient, Rural, Urban, VA/Military

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