Hypertrophic Tongue Papillae in Cowden Syndrome – PTEN
This case report describes a woman in her 60s with hypertrophy of dorsal tongue papillae in a honeycomb pattern along with papillomatous growth of the gingiva.
ABMS Lifelong Learning CME Activity
A Patient With Cough, Palpitations, Dyspnea, and Chest Pain
A man in his early 50s presented with recurrent episodes of cough, palpitations, shortness of breath, and exertional chest pain. What would you do next?
Patent Foramen Ovale and Dysarthria in a Man in His 60s
This case report describes a diagnosis of patent foramen ovale in a man in his 60s presenting with stroke symptoms and multifocal infarcts on magnetic resonance imaging of the brain.
Augmented Enteral Protein During Critical Illness – The TARGET Protein Randomized Clinical Trial
Importance Guidelines recommend augmenting enteral protein during critical illness, but the impact on patient outcomes is uncertain. Objective To determine whether augmenting enteral protein increases days alive and free from hospitalization. Design, Setting, and Participants This cluster randomized, crossover, open-label trial recruited critically…
Rescheduling Cannabis—Medicine or Politics?
Importance In 2023, the US Department of Health and Human Services (HHS) issued a letter to the administrator of the Drug Enforcement Administration (DEA) recommending rescheduling of cannabis (marijuana) from Schedule I to Schedule III under the Controlled Substances Act (CSA)….
Tipping Point Analysis – Assessing the Potential Impact of Missing Data
This JAMA Guide to Statistics and Methods explains tipping point analysis, which assesses how a range of hypothetical patterns in missing outcome data in a randomized clinical trial (RCT) would affect the study’s conclusions, and examines its use in an…
Adrenal Insufficiency in Adults – A Review
Importance Adrenal insufficiency is a syndrome of cortisol deficiency and is categorized as primary, secondary, or glucocorticoid induced. Although primary and secondary adrenal insufficiency are rare, affecting less than 279 per 1 million individuals, glucocorticoid-induced adrenal insufficiency is common. Observations Primary adrenal…
Modernizing Research and Evidence Consensus Definitions – A Food and Drug Administration–National Institutes of Health Collaboration
Importance The US Food and Drug Administration (FDA) and National Institutes of Health (NIH) share a mutual interest in facilitating efficient, well-designed clinical studies of drugs, devices, and biological products. Recent advances in science and technology, as well as innovative approaches…
Addictive Screen Use Trajectories and Suicidal Behaviors, Suicidal Ideation, and Mental Health in US Youths
Importance Increasing child and adolescent use of social media, video games, and mobile phones has raised concerns about potential links to youth mental health problems. Prior research has largely focused on total screen time rather than longitudinal addictive use trajectories. Objectives To…
Foot Lesions and Perianal Lump in an Adult Woman
A 50-year-old woman presented to the dermatology department with a 10-year history of recurrent plaque outbreaks between her toes and a history of Bowen disease in the anus that had been treated with excision and skin grafting. What is your…
