A Case of Gastric Thickening and a Large Ovarian Mass
A 35-year-old female patient with hypothyroidism and Ehler-Danlos syndrome presents with fatigue, abdominal distension, and dyspnea. What is your diagnosis?
JAMA Oncology
Lymphoma With a Skin Rash
A 62-year-old female had a generalized vesiculobullous rash on her face for 4 months. It started over the lips and gradually progressed to involve the oral mucosa and skin of the whole body. What is your diagnosis?
Current Management of Desmoid Tumors – A Review
Importance Desmoid tumor (DT) is a rare and locally aggressive monoclonal, fibroblastic proliferation characterized by a variable and often unpredictable clinical course. Previously, surgery was the standard primary treatment modality; however, within the past decade, a paradigm shift toward less-invasive management…
Obstacles to Biosimilar Acceptance and Uptake in Oncology – A Review
Importance Biosimilar drugs provide cost-effective yet clinically indistinguishable replications of target drugs. During initial development, this class of biologic medicines was expected to revolutionize pharmaceutical markets; however, following US Food and Drug Administration approval of the first biosimilar drug in 2015,…
Metastatic Hormone-Sensitive Prostate Cancer and Combination Treatment Outcomes – A Review
Importance Metastatic hormone-sensitive prostate cancer is currently an incurable disease. Despite a high response rate to androgen-deprivation therapy, most cases progress to castration-resistant disease, the terminal phase. This review provides a summary of the most recent evidence for current and emerging…
Immune Checkpoint Inhibitor Therapy Before Nephrectomy for Locally Advanced and Metastatic Renal Cell Carcinoma – A Review
Importance The therapeutic landscape of advanced renal cell carcinoma (RCC) has rapidly evolved in the past 2 decades, with the advent of cytokines therapy followed by targeted therapies and novel immune checkpoint inhibitors (ICI). This article aims to review the current…
PARP Inhibitors for Breast Cancer Treatment – A Review
Importance Poly(adenosine diphosphate–ribose) polymerase (PARP) inhibitors have revolutionized the treatment of patients with germline BRCA1/2-associated breast cancer, representing the first targeted therapy capable of improving outcomes in patients with hereditary tumors. However, resistance to PARP inhibitors occurs in almost all patients. Observations This…
Decentralized Clinical Trials as a New Paradigm of Trial Delivery to Improve Equity of Access
Importance The need to maintain clinical trial recruitment during the COVID-19 pandemic has precipitated the rapid uptake of digital health for the conduct of clinical trials. Different terms are used in different jurisdictions and clinical contexts, including digital trials, networked trials,…
American Radium Society Appropriate Use Criteria for Unresectable Locally Advanced Non Small Cell Lung Cancer
Importance The treatment of locally advanced non–small cell lung cancer (LA-NSCLC) has been informed by more than 5 decades of clinical trials and other relevant literature. However, controversies remain regarding the application of various radiation and systemic therapies in commonly encountered…
Rapid Advances in Resectable NonSmall Cell Lung Cancer – A Narrative Review
Importance A series of high-profile clinical trials for patients with resectable early-stage non–small cell lung cancer (NSCLC) have recently changed the standard of care in this setting. Specifically, studies have demonstrated statistically and clinically significant improvements in efficacy with the targeted…
