Activity ID



March 27, 2023

Format Type


CME Credit




CME Provider: JAMA

Description of CME Course

In this issue of JAMA, Shen et al report findings from a preliminary study of 5 severely ill patients with coronavirus disease 2019 (COVID-19) who were treated in the Shenzhen Third People’s Hospital, China, using plasma from recovered individuals. All patients had severe respiratory failure and were receiving mechanical ventilation; 1 needed extracorporeal membrane oxygenation (ECMO) and 2 had bacterial and/or fungal pneumonia. Four patients without coexisting diseases received convalescent plasma around hospital day 20, and a patient with hypertension and mitral valve insufficiency received the plasma transfusion at day 10. The donor plasma had demonstrable IgG and IgM anti–SARS-CoV-19 antibodies and neutralized the virus in in vitro cultures. Although these patients continued to receive antiviral treatment primarily with lopinavir/ritonavir and interferon, the use of convalescent plasma may have contributed to their recovery because the clinical status of all patients had improvement approximately 1 week after transfusion, as evidenced by normalization of body temperature as well as improvements in Sequential Organ Failure Assessment scores and Pao2/Fio2 ratio. In addition, the patients’ neutralizing antibody titers increased and respiratory samples tested negative for SARS-CoV-2 between 1 and 12 days after transfusion.

1. This activity is accredited by the American Medical Association.
2. This activity is free to AMA members.


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Educational Objectives

To understand the challenges and need for RCTs on convalescent plasma


Bleeding and Transfusion, Coronavirus (COVID19), Infectious Diseases, Pathology and Laboratory Medicine, Pulmonary Medicine


Medical Knowledge

CME Credit Type

AMA PRA Category 1 Credit

Additional Information


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