Activity ID



November 18, 2025

Format Type


CME Credit




CME Provider: JAMA

Description of CME Course

A 6-year-old boy taking no regular medications had persistent fever and cough for 15 days. Physical examination revealed eyelid swelling; vesiculobullous lesions on the palms and soles; vesicles and erosions on the face, trunk, and limbs; erosions on the lips and oral mucosa; and blisters on the anal mucosa. Laboratory testing revealed leukocytosis, and lung auscultation revealed bilateral crackles. What is the diagnosis and what would you do next?


1. This activity is accredited by the American Medical Association.
2. This activity is free to AMA members.

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NOTE: If a Member Board has not deemed this activity for MOC approval as an accredited CME activity, this activity may count toward an ABMS Member Board’s general CME requirement. Please refer directly to your Member Board’s MOC Part II Lifelong Learning and Self-Assessment Program Requirements.

Educational Objectives

Based on this clinical scenario and the accompanying image, understand how to arrive at a correct diagnosis.


Clinical Challenge, Dermatology, Infectious Diseases, Otolaryngology, Pediatrics


Medical Knowledge

CME Credit Type

AMA PRA Category 1 Credit



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